FH behaved exacty as normal by opening my default Project immediately in the Focus Window with a Property Box displayed.
So what could be different in your FH settings?
Closely inspect the Tools > Preferences > Startup tab Default Startup File value and check it is valid.
Perhaps use the Select... button to reselect the desired Project Gedcom (.ged) file.
Closely inspect the File > Project Window > Location and check it is valid.
One thing about Safe Mode is I believe it uses standard Drivers for Printers and Monitors rather than proprietary manufacturer Drivers that may be causing the problem.
So although they don't exactly fit your symptoms have a look at how_to:family_historian_installation_problems|> Family Historian Installation Problems under Error: Family Historian Stopped Working and Family Historian Installs But Won't Run Properly:
- Try the Data Execution Prevention (DEP) fix.
- Try setting the default Printer to Family Historian PDF.
- If you have an NVIDIA graphics card, try updating its Driver.